| 货号 | 16118-5mg |
| 描述 | Boc-D-FMK is a cell-permeable, irreversible pan-caspase inhibitor.1,2 Also known as Boc-D(OMe)-FMK, this compound contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Boc-D-FMK blocks apoptosis stimulated by TNF-α in neutrophils (IC50 = 39 µM), by bile duct ligation in hepatocytes, and by TNF-α in renal endothelial cells.3,4,5 The FMK pharmacophore is known to interact with non-caspase cysteine proteases, presumably explaining why Boc-D-FMK also inhibits cathepsins H and L.1 |
| 别名 | BAF;Boc-Asp(OMe)-FMK;Boc-D-Fluoromethyl Ketone;Boc-D(OMe)-FMK; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chauvier, D.,Ankri, S.,Charriaut-Marlangue, C., et al. Broad-spectrum caspase inhibitors: From myth to reality? Cell Death and Differentiation 14(2), 387-391 (2007). 2.Gregoli, P.A. and Bondurant, M.C. Function of caspases in regulating apoptosis caused by erythropoietin deprivation in erythroid progenitors. J.Cell Physiol. 178(2), 133-143 (1999). 3.Cowburn, A.S.,White, J.F.,Deighton, J., et al. z-VAD-fmk augmentation of TNFα-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species. Blood 105(7), 2970-2972 (2005). 4.Sheen-Chen, S.M.,Hung, K.S. and Eng, H.L. Effect of Boc-D-Fmk on hepatocyte apoptosis after bile duct ligation in rat and survival rate after endotoxin challenge. Journal of Gastroenterology and Hepatology 23(8 Pt 1), 1276-1279 (2008). 5.Wu, X.,Guo, R.,Chen, P., et al. TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho- and myosin light chain kinase-dependent mechanism. Am.J.Physiol.Renal.Physiol. 297(2), F316-F326 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 263.3 |
| 分子式 | C11H18FNO5 |
| CAS号 | 187389-53-3 |
| 稳定性 | ≥ 2 years |
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