| 货号 | 5428/1 |
| 别名 | (1S,2R,3S,4R,5S)-4-[6-[[(3-Chloroph |
| 供应商 | Tocris |
| 生物活性 | High affinity and selective A3 adenosine receptor agonist (Ki ~ 3 nM); displays >1000-fold selectivity over A1 and A2A adenosine receptors. Reverses mechanoallodynia in several neuropathic pain models in vivo. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >96 % |
| 计算分子量 | 564.97 |
| 分子式 | C28H23ClF2N6 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| 参考文献 | Littleet al (2015) Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain 138 28. PMID: 25414036. Toshet al (2015) Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain. Purinergic Signal. 11 371. PMID: 26111639. Toshet al (2012) Structure-guided design of A3 adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions. J.Med.Chem. 55 4847. PMID: 22559880. |