| 货号 | 3763/10 |
| 别名 | 1-[1-(1-Methylcyclooctyl)-4-piperid |
| 供应商 | Tocris |
| 生物活性 | High affinity NOP receptor agonist (pKi = 10.07 for the human NOP receptor). Exhibits anxiolytic effects with no effect on memory or locomotion. Regarded as one of the most potent, non-peptide NOP full agonists in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 534.05 |
| 分子式 | C26H40N4.3HCl |
| 可溶性/溶解性 | Soluble to 30 mM in water and to 60 mM in DMSO |
| 参考文献 | Hayashiet al (2009) Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain for orally potent antianxiety drug. J.Med.Chem. 52 610. PMID: 19125610. Hiraoet al (2008) Pharmacological characterization of the newly synthesized nociceptin/orphanin FQ-receptor agonist 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole as an anxiolytic agent. J.Pharmacol.Sci. 106 361. PMID: 18319566. |