| 货号 | 3492/1 |
| 别名 | Adrenocorticotropic hormone (1-39) |
| 供应商 | Tocris |
| 生物活性 | Potent endogenous melanocortin receptor 2 (MC2) agonist (EC50 = 57 pM). Component of the hypothalamic-pituitary-adrenal (HPA) axis that stimulates glucocorticoid production and release from the adrenal cortex. Induces insulin resistance, promotes a proinflammatory profile and stimulates UCP-1 in adipocytes in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4541.1 |
| 分子式 | C207H308N56O58S |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 12279-41-3 |
| 序列号 | SYSMEHFRWGKPVGKKRRPVKVYPNGAEDE |
| 参考文献 | Bertoliniet al (2009) Brain effects of melanocortins. Pharmacol.Res. 59 13. PMID: 18996199. Iwenet al (2008) Melanocortin crosstalk with adipose functions: ACTH directly induces insulin resistance, promotes a pro-inflammatory adipokine profile and stimulates UCP-1 in adipocytes. J.Endocrinol. 196 465. PMID: 18310442. Kapaset al (1996) Agonist and receptor binding properties of adrenocorticotropin peptides using the cloned mouse adrenocorticotropin receptor expressed in a stably transfected HeLa cell line. Endocrinology 137 3291. PMID: 8754753. |