Maraviroc
货号：
14641-50mg 基本售价：
5012.0 元 规格：
50 mg
产品信息
概述| 货号 | 14641-50mg |
| 描述 | Maraviroc is an antagonist of the C-C chemokine receptor type 5 (CCR5), inhibiting binding of the ligand RANTES with an IC50 value of 1.4 nM.1 Because human immunodeficiency virus (HIV) uses CCR5 to enter monocytes and macrophages, maraviroc inhibits HIV-1 replication in CCR5-expressing cells (IC50 = 2.8 nM).1 The pharmacokinetics of maraviroc in healthy male subjects have been delineated.2 |
| 别名 | Celsentri;Selzentry;UK 427857; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lemoine, R.C.,Petersen, A.C.,Setti, L., et al. Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc. Bioorganic & Medicinal Chemistry Letters 20(5), 1674-1676 (2010).
2.Abel, S.,Russel, D.,Whitlock, L.A., et al. Assessment of the absorption, metabolism and absolute bioavailability of maraviroc in healthy male subjects. British Journal of Clinical Pharmacology 65(1), 60-67 (2008).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 513.7 |
| 分子式 | C29H41F2N5O |
| CAS号 | 376348-65-1 |
| 稳定性 | ≥ 2 years |
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