| 货号 | 5139/50 |
| 别名 | 4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H |
| 供应商 | Tocris |
| 生物活性 | Antagonist of the angiotensin II type 1 receptor (AT1) (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPARγ receptors; shown to improve insulin sensitivity in rodents receiving high fat diets. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 514.62 |
| 分子式 | C33H30N4O2 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Ronget al (2009) An adipose tissue-independent insulin-sensitizing action of telmisartan: a study in lipodystrophic mice. J.Pharmacol.Exp.Ther. 331 1096. PMID: 19770292. Bensonet al (2004) Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPAR γ-modulating activity. Hypertension 43 993. PMID: 15007034. Rieset al (1993) 6-substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships. J.Med.Chem. 36 4040. PMID: 8258826. |