| 货号 | 4418/50 |
| 别名 | (2S)-N1-[(1S,2R)-3-[(3S,4aS,8aS)-3- |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of human immunodeficiency virus (HIV) protease (Ki values are <0.1 and 0.12 nM for HIV-2 and HIV-1 protease respectively). Exhibits high antiviral activity and low cytotoxicity. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 766.95 |
| 分子式 | C38H50N6O5 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Kaldoret al (1995) Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease. Bioorg.Med.Chem.Lett. 5721. Krausslichet al (1992) Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formation. J.Virol. 66 567. PMID: 1727499. Tuckeret al (1992) A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity. J.Med.Chem. 35 2525. PMID: 1635054. Robertset al (1990) Rational design of peptide-based HIV proteinase inhibitors. Science 248 358. PMID: 2183354. |