| 货号 | 5294/50 |
| 别名 | 4-Methyl-5-(2-pyrazinyl)-3H-1,2-dit |
| 供应商 | Tocris |
| 生物活性 | Nrf2 activator; activates Nrf, which binds to antioxidant response elements (AREs) and induces Phase-I and -II drug-metabolizing enzymes including CYP2B and NQO1. Also increases mRNA levels of multiple hepatic xenobiotic transporters. Elevates expression of genes encoding anti-oxidant and multidrug resistance-associated proteins. Displays chemopreventive activity. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 226.34 |
| 分子式 | C8H6N2S3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Merrellet al (2008) Induction of drug metabolism enzymes and transporters by oltipraz in rats. J.Biochem.Mol.Toxicol. 22 128. PMID: 18418891. Maheret al (2007) Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology 46 1597. PMID: 17668877. Manandharet al (2007) Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. Eur J Pharmacol. 577 17. PMID: 17854798. |