| 货号 | 1984/1 |
| 供应商 | Tocris |
| 生物活性 | Peptide fragment corresponding to residues 1 - 40 of Nogo-66, the domain of the myelin protein Nogo that inhibits axonal outgrowth. Acts as a competitive antagonist at the Nogo-66 receptor (NgR); blocks Nogo-66- and CNS myelin-induced inhibition of axonal growth, but does not reduce myelin-associated glycoprotein (MAG) inhibition of neurite outgrowth in vitro. Promotes regeneration of hemisected spinal axons and locomotor recovery following spinal injury in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4625.16 |
| 分子式 | C206H324N56O65 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 475221-20-6 |
| 序列号 | RIYKGVIQAIQKSDEGHPFRAYLESEVAIS (Modifications: Arg-1 = N-terminal Ac, Ser-40 = C-terminal amide) |
| 参考文献 | Li and Strittmatter (2003) Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury. J.Neurosci. 23 4219. PMID: 12764110. GrandPreet al (2002) Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature 417 547. PMID: 12037567. Liuet al (2002) Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 297 1190. PMID: 12089450. |