| 货号 | 5357/50 |
| 别名 | N-(4-Butylphenyl)-4-fluorobenzenesu |
| 供应商 | Tocris |
| 生物活性 | Free fatty acid receptor 1 (FFA1/GPR40) antagonist. Inhibits FFA-induced increases in intracellular Ca2+ levels and suppresses palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic βcellsin vitro. Decreases serum insulin levels, improves insulin sensitivity and reduces the number of apoptotic pancreatic β cells in obese diabetic (db/db) rats. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 307.38 |
| 分子式 | C16H18FNO2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Sunet al (2013) DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. PLoS ONE 8 e66744. PMID: 23776696. Zhanget al (2010) DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats. Biomed.Pharmacother. 64 647. PMID: 20888730. Huet al (2009) A novel class of antagonists for the FFAs receptor GPR40. Biochem.Biophys.Res.Comm. 390 557. PMID: 19818732. |