Torin 2
货号：
14185-25mg 基本售价：
4984.0 元 规格：
25 mg
产品信息
概述| 货号 | 14185-25mg |
| 描述 | Torin 2 is a potent and selective inhibitor of cellular mTOR activity (EC50 = 0.3 nM).1 It shows more than 800-fold selectivity for mTOR over PI3K (EC50 = 200 nM) and greater than 100-fold binding selectivity relative to 440 other protein kinases.1 Torin 2 has significantly improved bioavailability (54%), metabolic stability, and plasma exposure compared to Torin 1 (Item No. 10997).1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liu, Q.,Wang, J.,Kang, S.A., et al. Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective and orally available mTOR inhibitor for treatment of cancer. Journal of Medicinal Chemistry 54(5), 1473-1480 (2011).
2.Thoreen, C.C.,Kang, S.A.,Chang, J.W., et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. The Journal of Biological Chemisty 284(12), 8023-8032 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 432.4 |
| 分子式 | C24H15F3N4O |
| CAS号 | 1223001-51-1 |
| 稳定性 | ≥ 2 years |
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