| 货号 | 10664-100ug |
| 描述 | Hormone-sensitive lipase (HSL) is a key enzyme regulating the mobilization of fatty acids from intracellular stores.1 There are three different isoforms of the enzyme: HSLadi, which is the predominant form found in adipocytes, HSLtes expressed in testes, and HSLb found in insulin secreting b-cells.2 The three isoforms are distinguished by their molecular masses.2 HSL catalyses the rate limiting step in the lipolysis of triacylglycerol, found in intracellular stores, to fatty acids.3 HSL also catalyzes the hydrolysis of mono- and diacylglycerides, as well as cholesterol esters.4 |
| 别名 | HSL;LIPE; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Holm, C.,Belfrage, P.,Osterlund, T., et al. Hormone-sensitive lipase: Structure, function, evolution and overproduction in insect cells using the baculovirus expression system. Protein Engineering 7(4), 537-541 (1994). 2.Krintel, C.,Klint, C.,Lindvall, H., et al. Quarternary structure and enzymological properties of the different hormone-sensitive lipase (HSL) isoforms. PLoS One 5(6), (2010). 3.Zimmermann, R.,Lass, A.,Haemmerle, G., et al. Fate of fat: The role of adipose triglyceride lipase in lipolysis. Biochimica et Biophysica Acta 1791, 494-500 (2009). 4.Saltiel, A.R. Another hormone-sensitive triglyceride lipase in fat cells. Proceedings of the National Academy of Sciences of the United States of America 97(2), 535-537 (2000). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥80% estimated by SDS-PAGE |
| 稳定性 | ≥ 6 months |
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