Cystathionine γ-Lyase (human recombinant)
货号：
10329-100ug 基本售价：
4970.0 元 规格：
100 ug
产品信息
概述| 货号 | 10329-100ug |
| 描述 | Transsulfuration and reverse transsulfuration comprise part of the metabolic interconversion of the sulfur-containing amino acids cysteine and methionine.1 Reverse transsulfuration is catalyzed by the enzymes cystathionine β-synthase (CBS) and cystathionine γ-lyase (CGL) in fungi and mammals.1 Specifically, CGL catalyzes the conversion of cystathionine to cysteine in a pyridoxal-5-phosphate-dependant reaction.2 At elevated levels, homocysteine is an independent risk factor for cardiovascular diseases and other complex disorders.2 The mammalian transsulfuration pathway is one of two major metabolic routes for homocysteine removal. Besides homocysteine removal, transsulfuration contributes significantly to the intracellular cysteine pool.2 Cysteine is used for biosynthesis of glutathione, and is also the primary substrate for H2S biosynthesis. CGL is one of two major enzymes that catalyzes the formation of H2S from cysteine. 2H2S generation is a biological gasotransmitter, a neuromodulator, a vasodilator, and plays an important role in inflammation.2 |
| 别名 | CGL;CTH;Cystathionase; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Steegborn, C.,Clausen, T.,Sondermann, P., et al. Kinetics and inhibition of recombinant human cystathionine γ-lyase. Toward the rational control of transsulfuration. The Journal of Biological Chemisty 274(18), 12675-12684 (1999).
2.Zhu, W.,Lin, A. and Banerjee, R. Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine γ-lyase. Biochemistry 47, 6226-6232 (2008).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥70%(estimated by SDS-PAGE) |
| 稳定性 | ≥ 1 year |
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