| 货号 | 10316-100ug |
| 描述 | The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group.1,2,3 There are seven human sirtuins, which have been designated SIRT1-SIRT7.4 SIRT7 has been shown to activate transcription by RNA polymerase I and deacetylate p53.5 SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart.6 |
| 别名 | NAD-dependent deacetylase 7;Silent Information Regulator 7;Sirtuin 7;SIR2L7;SIR2-like protein 7; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Imai, S.I.,Armstrong, C.M.,Kaeberlein, M., et al. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795-800 (2000). 2.Tanner, K.G.,Landry, J.,Sternglanz, R., et al. Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proceedings of the National Academy of Sciences of the United States of America 97(26), 14178-14182 (2000). 3.Tanny, J.C. and Moazed, D. Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product. Proceedings of the National Academy of Sciences of the United States of America 98(2), 415-420 (2001). 4.Frye, R.A. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochemical and Biophysical Research Communications 273, 793-798 (2000). 5.Lavu, S.,Boss, O.,Elliot, P.J., et al. Sirtuins-novel therapeutic targets to treat age-associated diseases. Nature Reviews.Drug Discovery 7, 841-853 (2008). 6.Vakhrusheva, O.,Smolka, C.,Gajawada, P., et al. Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circulation Research 102, 703-710 (2008). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥35% estimated by SDS-PAGE |
| 稳定性 | ≥ 6 months |
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