| 货号 | 10315-100ug |
| 描述 | The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group.1,2,3 There are seven human sirtuins, which have been designated SIRT1-7.4 SIRT6 associates specifically with telomeres and functions at chromatin to decrease NF-κB signaling.5,6 Mammalian cells depleted of SIRT6 display abnormal telomere structures similar to defects found in Werner syndrome, a premature ageing disorder, and have a shortened life span.5,6 Since SIRT6 binds and attenuates NF-κB signaling, it is proposed that activators of SIRT6 may be effective anti-cancer and anti-inflammatory drugs and may increase longevity.5 |
| 别名 | NAD-dependent Deacetylase 6;Silent Information Regulator 6;SIR2L6;SIR2-like Protein 6;Sirtuin 6; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Imai, S.I.,Armstrong, C.M.,Kaeberlein, M., et al. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795-800 (2000). 2.Tanner, K.G.,Landry, J.,Sternglanz, R., et al. Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proceedings of the National Academy of Sciences of the United States of America 97(26), 14178-14182 (2000). 3.Tanny, J.C. and Moazed, D. Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product. Proceedings of the National Academy of Sciences of the United States of America 98(2), 415-420 (2001). 4.Frye, R.A. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochemical and Biophysical Research Communications 273, 793-798 (2000). 5.Kawahara, T.L.A.,Michishita, E.,Adler, A.S., et al. SIRT6 links histone H3 lysine 9 deacetylation to NF- k B-dependent gene expression and organismal life span. Cell 136, 62-74 (2009). 6.Michishita, E.,McCord, R.A.,Berber, E., et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 452, 492-496 (2008). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥80% estimated by SDS-PAGE |
| 稳定性 | ≥ 6 months |
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