11β-Hydroxysteroid Dehydrogenase
货号：
10007815-100ug 基本售价：
4970.0 元 规格：
100 ug
产品信息
概述| 货号 | 10007815-100ug |
| 描述 | 11-β-Hydroxysteroid dehydrogenase (11β-HSD) exists as two isozymes 11β-HSD1 and 11β-HSD2.1 Both isoforms are members of the short-chain dehydrogenase/reductase (SDRs) family.2 11β-HSD1 is a membrane-bound glycoprotein localized on the endoplasmic reticulum. The main catalytic domain of 11β-HSD1 lies within the lumen of the ER. A short five amino acid N-terminal region extends into the cytoplasm and is linked to the catalytic portion through a single transmembrane helix.1 11β-HSD1 is a relatively low affinity NADP-dependent enzyme with a bidirectional catalytic activity. The dehydrogenase reductase activity of 11β-HSD1 catalyzes the conversion of cortisol to cortisone. The primary function of 11β-HSD1 is the oxoreduction of cortisone to the active glucocorticoid cortisol.2 Cortisol is a steroid hormone essential for a variety of physiological and homeostatic functions. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Walker, E.A.,Clark, A.M.,Hewison, M., et al. Functional expression, characterization, and purification of the catalytic domain of human 11-β-hydroxysteroid dehydrogenase type 1. The Journal of Biological Chemisty 276(24), 21343-21350 (2001).
2.Blum, A.,Martin, H.J., and Maser, E. Human 11β-hydroxysteroid dehydrogenase type 1 is enzymatically active in its nonglycosylated form. Biochemical and Biophysical Research Communications 276, 428-434 (2000).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% estimated by SDS-PAGE |
| 稳定性 | ≥ 6 months |
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