| 货号 | 14585-50mg |
| 描述 | SR 95531 is a derivative of γ-aminobutyric acid (GABA) that acts as an antagonist of GABAA receptors (Ki = 74-150 nM).1,2,3 When administered intravenously, it elicits seizures in mice.1 SR 95531 differs in action from bicuculline (Item No. 11727) in that it antagonizes GABA-induced chloride currents but not those induced by pentobarbitone.4 It is effective against GABAA receptor isoforms from mice, rats, and humans.1,2,5 |
| 别名 | Gabazine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Heaulme, M.,Chambon, J.P.,Leyris, R., et al. Biochemical characterization of the interaction of three pyridazinyl-GABA derivatives with the GABAA receptor site. Brain Research 384, 224-231 (1986). 2.Melikian, A.,Schlewer, G.,Chambon, J.P., et al. Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists. Journal of Medicinal Chemistry 35(22), 4092-4097 (1992). 3.Krehan, D.,Storustovu, S.í.,Liljefors, T., et al. Potent 4-arylalkyl-substituted 3-isothiazolol GABAA competitive/noncompetitive antagonists: Synthesis and pharmacology. Journal of Medicinal Chemistry 49(4), 1388-1396 (2006). 4.Uchida, I.,Cestari, I.N. and Yang, J. The differential antagonism by bicuculline and SR95531 of pentobarbitone-induced currents in cultured hippocampal neurons. European Journal of Pharmacology 307(1), 89-96 (1996). 5.Mendu, S.K.,Bhandage, A.,Jin, Z., et al. Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes. PLoS One 7(8), (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 368.2 |
| 分子式 | C15H17N3O3 • HBr |
| CAS号 | 104104-50-9 |
| 稳定性 | ≥ 2 years |
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