| 货号 | 10497-100ug |
| 描述 | Very long chain polyunsaturated fatty acids (VLCPUFA) are present in retina, sperm, and brain.1,2,3 Though little is known of their biosynthesis or functional roles in these tissues, recent studies using the elongation of very long-chain FA-4 protein suggest a unique role for VLCPUFA in retinal development and macular degeneration.4,5 CAY10632 is a C32:6 VLCPUFA whose specific biological actions are largely unknown, but are thought to involve normal photoreceptor cell function in the retina.4,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Aveldaño, M.I. Phospholipid species containing long and very long polyenoic fatty acids remain with rhodopsin after hexane extraction of photoreceptor membranes. Biochemistry 27, 1229-1239 (1988). 2.Robinson, B.S.,Johnson, D.W. and Poulos, A. Novel molecular species of spingomyelin containing 2-hydroxylated polyenoic very-long-chain fatty acids in mammalian testes and spermatozoa. The Journal of Biological Chemisty 267, 1746-1751 (1992). 3.Robinson, B.S.,Johnson, D.W. and Poulos, A. Unique molecular species of phophatidylcholine containing very-long-chain (C24-C38) polyenoic fatty acids in rat brain. Biochemistry Journal 265, 763-767 (1990). 4.McMahon, A.,Jackson, S.N.,Woods, A.S., et al. A Stargardt disease-3 mutation in the mouse Elovl4 gene causes retinal deficiency of C32-C36 acyl phosphatidylcholines. FEBS Letters 581, 5459-5463 (2007). 5.Agbaga, M.P.,Mandal, M.N.A. and Anderson, R.E. Retinal very long-chain PUFAs: New insights from studies on ELOVL4 protein. Journal of Lipid Research 51, 1624-1642 (2010). 6.Agbada, M.P.,Brush, R.S.,Mandal, N.A., et al. Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids. Proceedings of the National Academy of Sciences of the United States of America 105(35), 12843-12848 (2008). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 468.8 |
| 分子式 | C32H52O2 |
| CAS号 | 105517-82-6 |
| 稳定性 | ≥ 1 year |
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