| 货号 | 15584-50mg |
| 描述 | Formoterol is an agonist of β-adrenergic receptors that activates the β1, β2, and β3 receptors with pEC50 values of 7.5, 9.0, and 6.8 respectively.1 It displays high selectivity for β-adrenoceptors in the trachea over those in atria.2 Formoterol activity is retained in the airway for extended periods, so it is classified as a long-acting β-receptor agonist.2 It has use, alone or in combination with other compounds, in chronic obstructive pulmonary disease and asthma.3,4,5 |
| 别名 | CGP 25827A;Foradil;NSC 299587;YM-08316; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Procopiou, P.A.,Barrett, V.J.,Ford, A.J., et al. The discovery of long-acting saligenin β2 adrenergic receptor agonists incorporating a urea group. Bioorganic & Medicinal Chemistry 19(20), 6026-6032 (2011). 2.Anderson, G.P. Formoterol: Pharmacology, molecular basis of agonism, and mechanism of long duration of a highly potent and selective β2-adrenoceptor agonist bronchodilator. Life Sciences 52(26), 2145-2160 (1993). 3.Decramer, M.L.,Hanania, N.A.,Lötvall, J.O., et al. The safety of long-acting β2-agonists in the treatment of stable chronic obstructive pulmonary disease. Int.J.Chron.Obstruct.Pulmon.Dis. 8, 53-64 (2013). 4.Tashkin, D.P. and Ferguson, G.T. Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease. Respiratory Research 14, 49 (2013). 5.Bush, A. and Saglani, S. Management of severe asthma in children. Lancet 376(9743), 814-825 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 402.5 |
| 分子式 | C19H24N2O4 • 1/2C4H4O4 |
| CAS号 | 43229-80-7 |
| 稳定性 | ≥ 2 years |
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