SMER3
货号：
15324-50mg 基本售价：
4914.0 元 规格：
50 mg
产品信息
概述| 货号 | 15324-50mg |
| 描述 | SMER3 is a selective inhibitor of Skp1-Cullin-F-box (SCF)MET30 ubiquitin ligase, an E3 ligase that regulates transcription, cell-cycle control, and immune response.1,2 It is a small molecule enhancer of rapamycin (Item No. 13346), in that it enhances yeast cell lethality in response to rapamycin.1 SMER3, at 5 μM, upregulates a set of methionine biosynthesis genes by altering the SCFMET30 complex, preventing ubiquitination of target proteins, including Met4.1 As ubiquitin E3 ligases are involved in tumorigenesis, SMER3 has potential applications in cancer research.3 |
| 别名 | SCFMET30 Inhibitor;MET30 Antagonist; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Aghajan, M.,Jonai, N.,Flick, K., et al. Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nat.Biotechnol. 28(7), 738-742 (2010).
2.Petroski, M.D. and Deshaies, R.J. Function and regulation of cullin-RING ubiquitin ligases. Nature Reviews.Molecular Cell Biology 6(1), 9-20 (2005).
3.Nalepa, G.,Rolfe, M. and Harper, J.W. Drug discovery in the ubiquitin-proteasome system. Nature Reviews.Drug Discovery 5(7), 596-613 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 224.2 |
| 分子式 | C11H4N4O2 |
| CAS号 | 67200-34-4 |
| 稳定性 | ≥ 2 years |
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