| 货号 | 21385-5mg |
| 描述 | GLYX 13 is a monoclonal antibody-derived tetrapeptide that acts as a partial agonist at the glycine site of the N-methyl-D-aspartate (NMDA) receptor.1,2 It is active in vivo when administered intravenously, and it readily passes through the blood-brain barrier.1,3 GLYX 13 has diverse effects in animals, as it blocks neuropathic pain, enhances learning and memory, and significantly reduces anxiety.2,3,4 GLYX 13 induces rapid antidepressant-like effects in animal models and rescued normal behavior in a rat model of autism.5,6,7 |
| 别名 | Rapastinel; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Moskal, J.R.,Kuo, A.G.,Weiss, C., et al. GLYX-13: a monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator. Neuropharmacology 49(7), 1077-1087 (2005). 2.Wood, P.L.,Mahmood, S.A., and Moskal, J.R. Antinociceptive action of GLYX-13: An N-methyl-D-aspartate receptor glycine site partial agonist. Neuroport. 19(10), 1059-1061 (2008). 3.Burgdorf, J.,Zhang, X.-l.,Weiss, C., et al. The N-methyl-D-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats. Neurobiol. Aging 32(4), 698-706 (2011). 4.Jin, Z.-L.,Liu, J.-X.,Liu, X., et al. Anxiolytic effects of GLYX-13 in animal models of posttraumatic stress disorder-like behavior. J. Psychopharmacol. 30(9), 913-921 (2016). 5.Burgdorf, J.,Zhang, X.-l.,Nicholson, K.L., et al. GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects. Neuropsychopharmacology 38(5), 729-742 (2013). 6.Santini, A.C.,Pierantoni, G.M.,Gerlini, R., et al. Glix 13, a new drug acting on glutamatergic pathways in children and animal models of autism spectrum disorders. Biomed. Res. Int. 2014, 234295 (2014). 7.Yang, B.,Zhang, J.-c.,Han, M., et al. Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression. Psychopharmacology 233(19-20), 3647-3657 (2016). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 413.5 |
| 分子式 | C18H31N5O6 |
| CAS号 | 117928-94-6 |
| 稳定性 | ≥ 2 years |
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