| 货号 | 6070/500U |
| 别名 | (4R,7R,8S,9E,11S,12S)-8-(Acetyloxy) |
| 供应商 | Tocris |
| 生物活性 | mRNA splicing inhibitor; decreases splicing capacity up to 75% in vitro. Directly targets splicesome-associated 130 (SAP130), inhibits splicing factor 3B subunit (SF3B1) and impairs U2 small nuclear ribonucleoprotein (U2 snRNP) interaction with pre-mRNA. Arrests cell cycle in G1 and G2/M phases. Displays antitumor activity against gastric cancer cells (IC50 values are 1.6-4.9 nM). Cell permeable and active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 536.7 |
| 分子式 | C30H48O8 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in DMSO |
| 参考文献 | Leeet al (2016) Therapeutic targeting of splicing in cancer. Nature Medicine 22976. Pederivaet al (2016) Splicing controls the ubiquitin response during DNA double-strand break repair. Cell Death Differ. 23 1648. PMID: 27315300. Satoet al (2014) High antitumor activity of pladienolide B and its derivative in gastric cancer. Cancer Sci. 105 110. PMID: 24635824. |