| 货号 | 1987/5U |
| 别名 | (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E |
| 供应商 | Tocris |
| 生物活性 | Antifungal antibiotic that is an inhibitor of the nuclear export of proteins; acts by binding directly to and inhibiting CRM1/exportin-1. Inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Antitumor in vitroandin vivo. |
| 运输条件 | Dry Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 540.74 |
| 分子式 | C33H48O6 |
| 可溶性/溶解性 | Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 27 |
| 参考文献 | Freedman and Levine (1998) Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol.Cell.Biol. 18 7288. PMID: 9819415. Kudoet al (1998) Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp.Cell Res. 242 540. PMID: 9683540. Wolffet al (1997) Leptomycin B is an inhibitor of nuclear export: inhibition of nucleocytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem.Biol. 4 139. PMID: 9190288. Robertset al(1986)In vivoandin vitro anticancer activity of the structurally novel and highly potent antibiotic CI 940 and its hydroxy analog (PD 114,721). Cancer Chemother.Pharmacol. 16 95. PMID: 3081269. |