| 货号 | 15021-50mg |
| 描述 | β-Lapachone is a natural quinone with diverse anti-cancer and anti-inflammatory effects. It inhibits topoisomerase I at 25 μM and transglutaminase (IC50 = 5 μM).1,2 In cancer cells which overexpress NAD(P)H:quinone oxidoreductase, β-lapachone is reduced to β-lapachone hydroquinone, which generates reactive oxygen species during its reversion to β-lapachone.3 This process sensitizes cancer cells to radiation, suppresses NF-κB activation, and drives apoptosis.3,4,5 |
| 别名 | ARQ 501;NSC 26326;NSC 629749;SL 11001; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Li, C.J.,Averboukh, L. and Pardee, A.B. β-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. The Journal of Biological Chemisty 268(30), 22463-22468 (1993). 2.Lai, T.S.,Liu, Y.,Tucker, T., et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chemistry & Biology 15(9), 969-978 (2008). 3.Siegel, D.,Yan, C. and Ross, D. NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Biochemical Pharmacology 83(8), 1033-1040 (2012). 4.Dong, G.Z.,Oh, E.T.,Lee, H., et al. β-Lapachone suppresses radiation-induced activation of nuclear factor-κB. Experimental and Molecular Medicine 42(5), 327-334 (2010). 5.Li, L.S.,Bey, E.A.,Dong, Y., et al. Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy. Clinical Cancer Research 17, 275-285 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 242.3 |
| 分子式 | C15H14O3 |
| CAS号 | 4707-32-8 |
| 稳定性 | ≥ 2 years |
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