| 货号 | 14189-1mg |
| 描述 | Chrysomycin B is an antibiotic isolated from a strain of Streptomyces.1 It differs from its analog chrysomycin A (Item No. 14188) by having a methyl, rather than vinyl, group in the 8-position of the chromophore.2,3 Like its analog, chrysomycin B suppresses the growth of transplantable tumors in mice, an effect that may be related to its ability to bind DNA.3,4,5 It also causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibits topoisomerase II.5 Chrysomycin B is structurally very similar to gilvocarcin V, which promotes DNA cross-linking with histone 3 and GRP78 when photoactivated by near-UV light.6 |
| 别名 | Albacarcin M;Virenomycin M; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Strelitz, F.,Flon, H. and Asheshov, I.N. Chrysomycin: A new antibiotic substance for bacterial viruses. Journal of Bacteriology 69(3), 280-283 (1955). 2.Weiss, U.,Yoshihira, K.,Highet, R.J., et al. The chemistry of the antibiotics chrysomycin A and B. Antitumor activity of chrysomycin A. Journal of Antibiotics 35(9), 1194-1201 (1982). 3.Matson, J.A.,Rose, W.C.,Bush, J.A., et al. Antitumor activity of chrysomycins M and V. Journal of Antibiotics 42(9), 1446-1448 (1989). 4.Burres, N.S.,Frigo, A.,Rasmussen, R.R., et al. A colorimetric microassay for the detection of agents that interact with DNA. Journal of Natural Products 55(11), 1582-1587 (1992). 5.Lorico, A. and Long, B.H. Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II. European Journal of Cancer 29A, 1985-1991 (1993). 6.Matsumoto, A. and Hanawalt, P.C. Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated gilvocarcin V in human fibroblasts. Cancer Research 60(14), 3921-3926 (2000). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 496.5 |
| 分子式 | C27H28O9 |
| CAS号 | 83852-56-6 |
| 稳定性 | ≥ 1 year |
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