| 货号 | 14188-1mg |
| 描述 | Chrysomycin A is an antibiotic isolated from a strain of Streptomyces.1 It is structurally very similar to gilvocarcin V, an inhibitor of topoisomerase II which promotes DNA cross-linking with histone 3 and GRP78 when photoactivated by near-UV light.2,3,4 Chrysomycin A inhibits DNA synthesis in bacteria and suppresses the growth of transplantable tumors in mice.5,6 |
| 别名 | Albacarcin V;NSC 613946;Virenomycin V; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Strelitz, F.,Flon, H. and Asheshov, I.N. Chrysomycin: A new antibiotic substance for bacterial viruses. Journal of Bacteriology 69(3), 280-283 (1955). 2.Weiss, U.,Yoshihira, K.,Highet, R.J., et al. The chemistry of the antibiotics chrysomycin A and B. Antitumor activity of chrysomycin A. Journal of Antibiotics 35(9), 1194-1201 (1982). 3.Lorico, A. and Long, B.H. Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II. European Journal of Cancer 29A, 1985-1991 (1993). 4.Matsumoto, A. and Hanawalt, P.C. Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated gilvocarcin V in human fibroblasts. Cancer Research 60(14), 3921-3926 (2000). 5.Wei, T.T.,Byrne, K.M.,Warnick-Pickle, D., et al. Studies on the mechanism of action of gilvocarcin V and chrysomycin A. Journal of Antibiotics 35(4), 545-548 (1982). 6.Matson, J.A.,Rose, W.C.,Bush, J.A., et al. Antitumor activity of chrysomycins M and V. Journal of Antibiotics 42(9), 1446-1448 (1989). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 508.5 |
| 分子式 | C28H28O9 |
| CAS号 | 82196-88-1 |
| 稳定性 | ≥ 1 year |
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