SBE 13 (hydrochloride)
货号：
21241-50mg 基本售价：
4830.0 元 规格：
50 mg
产品信息
概述| 货号 | 21241-50mg |
| 描述 | SBE 13 is a potent inhibitor of polo-like kinase 1 (Plk1) (IC50 = 0.2 nM) that targets the inactive conformation of the enzyme 1,2. It exhibits no activity against aurora A kinase and less effectively inhibits Plk2 (IC50 > 66 µM) and Plk3 (IC50 = 875 nM). SBE 13 induces cell cycle arrest, reduces cell proliferation (EC50 = 5-60 µM), and induces apoptosis in a broad range of human cancer cell lines.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Keppner, S.,Proschak, E.,Schneider, G., et al. Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1. Chem. Med. Chem. 4(11), 1806-1809 (2009).
2.Keppner, S.,Proschak, E.,Kaufmann, M.T., et al. Biological impact of freezing Plk1 in its inactive conformation in cancer cells. Cell Cycle 9(4), 761-773 (2010).
3.Keppner, S.,Proschak, E.,Schneider, A., et al. Fate of primary cells at the G1/S boundary after polo-like kinase 1 inhibition by SBE13. Cell Cycle 10(4), 708-720 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 479.4 |
| 分子式 | C24H27ClN2O4 • HCl |
| CAS号 | 1052532-15-6 |
| 稳定性 | ≥ 2 years |
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