RN-486
货号：
20536-10mg 基本售价：
4830.0 元 规格：
10 mg
产品信息
概述| 货号 | 20536-10mg |
| 描述 | RN486 is a Bruton’s tyrosine kinase inhibitor (Kd = 0.31 nM; IC50 = 4 nM) that displays a high degree of selectivity when tested against a panel of 369 kinases.1 It has been shown to block Fcε receptor cross-linking-induced degranulation in mast cells (IC50 = 2.9 nM), Fcγ receptor engagement-mediated TNF-α production in monocytes (IC50 = 7 nM), and B cell antigen receptor-induced expression of CD69 in B cells whole blood (IC50 = 21 nM).1 RN486 is reported to produce anti-inflammatory and bone-protective effects in mouse collagen-induced arthritis and rat adjuvant-induced arthritis models.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Xu, D.,Kim, Y.,Postelnek, J., et al. RN486, a selective Bruton’s tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents. J. Pharmacol. Exp. Ther. 341(1), 90-103 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 606.7 |
| 分子式 | C35H35FN6O3 |
| CAS号 | 1242156-23-5 |
| 稳定性 | ≥ 2 years |
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