| 货号 | 16102-50ug |
| 描述 | Bone morphogenetic proteins (BMP) are secreted signaling proteins, many of which are involved in various developmental processes, in addition to bone formation.1 GDF11 is a circulating growth and differentiation factor that has age-dependent effects on development. Notably, injection of recombinant GDF11 into old mice, so that circulating levels match those in young mice, enhances vascularization in the brain, increases vessel volume, increases neural stem cell populations, and reverses cardiac hypertrophy.2,3 These changes mimic the changes in vascular remodeling, neurogenesis, and olfactory function that are produced by providing young blood to aged mice.2,3 In mouse embryos, GDF11 has critical roles in patterning mesodermal, skeletal, and neural tissues.4,5,6 |
| 别名 | BMP11;Growth/Differentiation Factor 11; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sakata, T. and Chen, J.K. Chemical Jekyll and Hyde’s: Small-molecule inhibitors of developmental signaling pathways. Chem.Soc.Rev. 40(8), 4318-4331 (2011). 2.Katsimpardi, L.,Litterman, N.K.,Schein, P.A., et al. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science 344(6184), 630-634 (2014). 3.Loffredo, F.S.,Steinhauser, M.L.,Jay, S.M., et al. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell 153(4), 828-839 (2013). 4.Nakashima, M.,Toyono, T.,Akamine, A., et al. Expression of growth/differentiation factor 11, a new member of the BMP/TGFβ superfamily during mouse embryogenesis. Mech.Dev. 80(2), 185-189 (1999). 5.McPherron, A.C.,Lawler, A.M. and Lee, S.J. Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11. Nature Genetics 22(3), 260-264 (1999). 6.Gamer, L.W.,Wolfman, N.M.,Celete, A.J., et al. A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos. Dev.Biol. 208(1), 222-232 (1999). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥90% estimated by SDS-PAGE |
| 稳定性 | ≥ 1 year |
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