Ac-VDVAD-AFC
货号：
14988-10mg 基本售价：
4830.0 元 规格：
10 mg
产品信息
概述| 货号 | 14988-10mg |
| 描述 | Ac-VDVAD-AFC is a fluorogenic substrate whose amino acids VDVAD have been shown to be a preferred cleavage site for caspase-2.1,2 Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm. Increases in Ac-VDVAD-AFC cleavage have been reported to correlate with nitric oxide-induced activation of caspase-2 and subsequent apoptosis in human neuroblastoma lines.1 |
| 别名 | N-Acetyl-Val-Asp-Val-Ala-Asp-7-amido-4-Trifluoromethylcoumarin;Caspase-2 Substrate (Fluorogenic); |
性能| 供应商 | Cayman |
| 应用文献 |
1.Moriya, R.,Uehara, T. and Nomura, Y. Mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cells. FEBS Letters 484(3), 253-260 (2000).
2.Talanian, R.V.,Quinlan, C.,Trautz, S., et al. Substrate specificities of caspase family proteases. The Journal of Biological Chemisty 272, 9677-9682 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 770.7 |
| 分子式 | C33H41F3N6O12 |
| CAS号 | 210344-94-8 |
| 稳定性 | ≥ 2 years |
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