p-nitro-Cyclic Pifithrin-α
货号：
17848-25mg 基本售价：
4816.0 元 规格：
25 mg
产品信息
概述| 货号 | 17848-25mg |
| 描述 | Pifithrin-α (PFT-α; Item No. 13326) is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.1 Cyclic PFT-α (Item No. 14748) is a stable analog of PFT-α.2p-nitro-Cyclic PFT-α is a cell-permeable form of cyclic PFT-α.3 It is one order of magnitude more active that PFT-α in protecting cortical neurons exposed to etoposide (ED50 = 30 nM).3p-nitro-Cyclic PFT-α acts in a p53-dependent manner but does not block phosphorylation of p53 on Ser15 in response to etoposide treatment, although it prevents p53 posttranscriptional activity.3 Although it is more stable in solution than the parent compound, this derivative is not active in vivo.3 |
| 别名 | Cyclic pifithrin-α-p-nitro;p-nitro-Cyclic PFT-α; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Komarov, P.G.,Komarova, E.A.,Kondratov, R.V., et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285, 1733-1737 (1999).
2.Walton, M.I.,Wilson, S.C.,Hardcastle, I.R., et al. An evaluation of the ability of pifithrin-α and -β to inhibit p53 function in two wild-type p53 human tumor cell lines. Molecular Cancer Therapeutics 4(9), 1369-1377 (2005).
3.Pietrancosta, N.,Moumen, A.,Dono, R., et al. Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: Discovery of a highly potent in vivo inhibitor and its action mechanism. Journal of Medicinal Chemistry 49(12), 3645-3652 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 299.3 |
| 分子式 | C15H13N3O2S |
| CAS号 | 60477-38-5 |
| 稳定性 | ≥ 2 years |
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