| 货号 | 14708-25mg |
| 描述 | 3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including protein kinase (PK)B, PKA, and certain isoforms of PKC.1 BX-912 is a potent, ATP-competitive inhibitor of PDK1 (IC50 = 26 nM).2 It less effectively inhibits a panel of related serine-threonine kinases.2 BX-912 has been used to evaluate the role of PDK1 in kinase activation and cell survival.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Peifer, C. and Alessi, D.R. Small-molecule inhibitors of PDK1. ChemMedChem 3(12), 1810-1838 (2008). 2.Feldman, R.I.,Wu, J.M.,Polokoff, M.A., et al. Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. The Journal of Biological Chemisty 280(20), 19867-19874 (2005). 3.Kloo, B.,Nagel, D.,Pfeifer, M., et al. Critical role of PI3K signaling for NF-κB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells. Proceedings of the National Academy of Sciences of the United States of America 108(1), 272-277 (2011). 4.Mashukova, A.,Forteza, R.,Wald, F.A., et al. PDK1 in apical signaling endosomes participates in the rescue of the polarity complex atypical PKC by intermediate filaments in intestinal epithelia. Molecular Biology of the Cell 23(9), 1664-1674 (2012). 5.Shibata, E.,Kanno, T.,Tsuchiya, A., et al. Free fatty acids inhibit protein tyrosine phosphatase 1B and activate Akt. Cell Physiology and Biochemistry 32(4), 871-879 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 471.4 |
| 分子式 | C20H23BrN8O |
| CAS号 | 702674-56-4 |
| 稳定性 | ≥ 2 years |
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