| 货号 | 10947-50ug |
| 描述 | Retinoblastoma-binding protein 5 (RbBP5) is a ubiquitously expressed nuclear protein that contains WD40 repeat-like domains. RbBP5 binds directly to tumor suppressor retinoblastoma protein (RB) and regulates cell proliferation. Interaction of RbBP5 occurs preferentially with underphosphorylated RB through the E1A-binding pocket B.1 RbBP5 is also an important component of the multi-subunit SET1 lysine methyltransferase protein complex, which includes MLL1.2 RbBP5 interacts directly with WDR5 contributing to the activation of the MLL1 core protein complex.3,4,5 MLL1-4 protein complexes catalyze the di- and trimethylation of histone H3 at lysine 4 (H3K4me2/me3), leading to the maintenance of global H3K4 trimethylation.6 |
| 别名 | RBQ3;Retinoblastoma binding Protein 5;SWD1, Set1c WD40 repeat protein, homolog; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sugano, M.,Tsuchida, K. and Makino, N. Nifedipine prevents apoptosis of endothelial cells induced by oxidized low-density lipoproteins. Journal of Cardiovascular Pharmacology 40(1), 146-152 (2002). 2.Steward, M.M.,Lee, J.S.,ODonovan, A., et al. Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Nature Structural & Molecular Biology 13(9), 852-854 (2009). 3.Avdic, V.,Zhang, P.,Lanouette, S., et al. Structural and biochemical insights into MLL1 core complex assembly. Structure 19(1), 101-108 (2011). 4.Odho, Z.,Southall, S.M. and Wilson, J.R. Characterization of a novel WDR5-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 lysine 4 by mixed lineage leukemia protein-1. The Journal of Biological Chemisty 285(43), 32967-32976 (2010). 5.Dou, Y.,Milne, T.A.,Ruthenburg, A.J., et al. Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nature Structural & Molecular Biology 13(8), 713-719 (2006). 6.Wang, P.,Lin, C.,Smith, E.R., et al. Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II. Molecular and Cellular Biology 29(22), 6074-6085 (2009). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥90% |
| 稳定性 | ≥ 6 months |
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