| 货号 | 2310/10 |
| 别名 | (2S)-1-[[(2R,3S)-5-Chloro-3-(2-chlo |
| 供应商 | Tocris |
| 生物活性 | Potent and selective non-peptide vasopressin V1A receptor antagonist; devoid of agonist activity. Displays high affinity and efficacy at both rat (Ki = 1.6 nM) and human (Ki = 1.1 - 6.3 nM) V1A receptors. Potently antagonizes arginine vasopressin-induced effects in vitro(IC50 = 3.7 nM for inhibition of human platelet aggregation) and is orally active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 620.5 |
| 分子式 | C28H27Cl2N3O7S |
| 可溶性/溶解性 | Soluble to 30 mM in DMSO |
| CAS号 | 150375-75-0 |
| 参考文献 | Tahtaouiet al (2003) Identification of the binding sites of the SR 49059 nonpeptide antagonist into the V1a vasopressin receptor using sulfydryl-reactive ligands and cysteine mutants as chemical sensors. J.Biol.Chem. 278 40010. PMID: 12869559. Serradeil-Le Galet al (1994) Binding of [3H]SR 49059, a potent nonpeptide vasopressin V1a antagonist, to rat and human liver membranes. Biochem.Biophys.Res.Comm. 199353. Serradeil-Le Galet al (1993) Biochemical and pharmacological properties of SR 49059, a new, potent, nonpeptide antagonist of rat and human vasopressin V1a receptors. J.Clin.Invest. 92 224. PMID: 8392086. |