| 货号 | 4034/1 |
| 供应商 | Tocris |
| 生物活性 | Peptide that reverses the anticoagulant effect of heparin (Cat. No. 2812). Potently binds heparin (Kd = 36 nM in vitro). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 5830 |
| 分子式 | C235H424N111O64 |
| 可溶性/溶解性 | Soluble to 5 mg/ml in water |
| CAS号 | 1234564-95-4 |
| 序列号 | AEARARRAAARAARRAKK(AEARARRAAAR (Modifications: Ala-1 = N-terminal Ac, Ala-19 = ε-Ac, X-36 = Dpr, Ala-37 = β-Ac, Glu-53 = C-terminal Amide) |
| 参考文献 | Cushinget al (2010) Reversal of heparin-induced increases in aPTT in the rat by PM102, a novel heparin antagonist. Eur.J.Pharmacol. 635 165. PMID: 20307530. Schicket al (2004) Novel concatameric heparin-binding peptides reverse heparin and low-molecular-weight heparin anticoagulant activities in patient plasma in vitro and in rats in vivo. Blood 1034. Shenoyet al (1999) Development of heparin antagonists with focused biological activity. Curr.Pharmaceut.Des. 5965. |