| 货号 | 1597/2 |
| 供应商 | Tocris |
| 生物活性 | Inhibitor peptide corresponding to last 10 amino acids of the C-terminus of the GluR2 AMPA receptor subunit. Disrupts binding of GluR2 (at the C-terminal PDZ site) with glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP) and protein interacting with C kinase (PICK1). Increases amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD). Control peptide available (Cat. No. 1597). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1284.47 |
| 分子式 | C60H93N13O18 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 328944-75-8 |
| 序列号 | YNVYGIESVKI |
| 参考文献 | Collingridge and Isaac (2003) Functional roles of protein interactions with AMPA and kainate receptors. Neurosci.Res. 47 3. PMID: 12941441. Kimet al (2001) Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Proc.Natl.Acad.Sci.U.S.A. 98 11725. PMID: 11573007. Dawet al (2000) PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron 28 873. PMID: 11163273. Liet al (1999) AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Nat.Neurosci. 2 972. PMID: 10526335. |