| 货号 | 1595/2 |
| 供应商 | Tocris |
| 生物活性 | Peptide inhibitor of the interaction between the C-terminus of the GluR2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates AMPA receptor function. Reduces postsynaptic currents in CA1 neurons, AMPA-mediated currents in cultured hippocampal neurons and AMPA receptor surface expression. Control peptide pep4c (Cat. No. 1596) also available. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1173.44 |
| 分子式 | C49H92N18O13S |
| 可溶性/溶解性 | Soluble to 2 mg/ml in 20% acetonitrile |
| CAS号 | 243843-42-7 |
| 序列号 | KRMKVAKNAQ |
| 参考文献 | Collingridge and Isaac (2003) Functional roles of protein interactions with AMPA and kainate receptors. Neurosci.Res. 47 3. PMID: 12941441. Luscheret al (1999) Role of AMPA receptor cycling in synaptic transmission and plasticity. Neuron 24 649. PMID: 10595516. Luthiet al (1999) Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction. Neuron 24 389. PMID: 10571232. Noelet al (1999) Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism. Neuron 23 365. PMID: 10399941. Nishimuneet al (1998) NSF binding to GluR2 regulates synaptic transmission. Neuron 21 87. PMID: 9697854. |