| 货号 | 1632/1 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective NK2 receptor antagonist (pA2 = 8.08, rabbit pulmonary artery). Displays > 250-fold selectivity over NK1(pA2 = 5.66, guinea pig ileum) and NK3(Ki > 10 mM, guinea pig brain). Active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1081.24 |
| 分子式 | C57H68N12O10 |
| CAS号 | 135306-85-3 |
| 序列号 | DYWVWWK (Modifications: Trp-3, Trp-5, Trp-6 = D-Trp, Lys-7 = C-terminal amide) |
| 参考文献 | Subramanianet al (1994) Pharmacological evidence of tachykinin-induced intracellular calcium rise in a human NK2 receptor transfected cell line. Biochem.Biophys.Res.Commun. 200 1512. PMID: 8185607. Barthoet al (1992) Tachykininergic transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of NK2 receptors. Br.J.Pharmacol. 105 805. PMID: 1380373. Maggiet al(1991)In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J.Pharmacol.Exp.Ther. 257 1172. PMID: 1710662. |