| 货号 | 2265/1 |
| 供应商 | Tocris |
| 生物活性 | Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in vitro. Inhibits airway eosinophilic inflammation in mouse model of asthma. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 2370.91 |
| 分子式 | C115H184N30O24 |
| 可溶性/溶解性 | Soluble to 10 mg/ml in water |
| CAS号 | 222018-18-0 |
| 序列号 | YGYRLRRKWEEKIPNP (Modifications: Tyr-1 = Octadecanoyl-Tyr, Pro-16 = C-terminal amide) |
| 参考文献 | Adachiet al (1999) The mapping of the Lyn kinase binding site of the common β subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. J.Immunol. 162 1496. PMID: 9973406. Adachiet al (1999) A novel lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. J.Immunol. 163 939. PMID: 10395690. |