| 货号 | 3202/100U |
| 供应商 | Tocris |
| 生物活性 | Potent irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50 = 0.1 nM). Prevents ADP-induced platelet aggregation via inhibition of glycoprotein IIb/IIIa (GpIIb/IIIa, αIIbβ3) receptors (IC50 = 30 nM) in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 5417.1 |
| 分子式 | C217H341N71O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | ECESGPCCRNCKFLKEGTICKRARGDDMDD (Modifications: Disulfide bridge between 2 - 11, 7 - 32, 8 - 37, 20 - 39) |
| 参考文献 | Kumaret al (1997) Biochemical characteriation of the binding of echistatin to integrin αVβ3 receptor. J.Pharmacol.Exp.Ther. 283 843. PMID: 9353406. Musialet al (1990) Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins RGD-containing peptides from viper venoms. Circulation 82 261. PMID: 2364514. Satoet al (1990) Echistatin is a potent inhibitor of bone resorption in culture. J.Cell.Biol. 111 1713. PMID: 2211834. |