| 货号 | 1776/1 |
| 供应商 | Tocris |
| 生物活性 | Control peptide version of dynamin inhibitory peptide, myristoylated (Cat. No. 1775), an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. In contrast to dynamin inhibitory peptide, has no significant effect on GABAA receptor-mediated miniature IPSPs. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1330.64 |
| 分子式 | C61H107N19O14 |
| 可溶性/溶解性 | Soluble to 0.67 mg/ml in 30% acetonitrile / water |
| 序列号 | QPPASNPRVR (Modifications: Gln-1 = Myr-Gln, Arg-10 = C-terminal amide) |
| 参考文献 | Nonget al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302. PMID: 12646920. Kittleret al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972. PMID: 11050117. Grabset al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419. PMID: 9148966. |