| 货号 | 1606/500U |
| 别名 | [D-Phe12, Nle21,38, Glu30, Lys33]-CRF (12-41) |
| 供应商 | Tocris |
| 生物活性 | Potent corticotropin-releasing factor (CRF) receptor antagonist (Ki values are 2, 1.5 and 1 nM at CRF1, CRF2α and CRF2β). Reduces ACTH secretion, blocks delayed gastric emptying and is neuroprotective in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 3563.2 |
| 分子式 | C161H269N49O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in 10% Acetic acid / water |
| 序列号 | FHLLREVLEXARAEQLAQEAHKNRKLXEII (Modifications: Phe-1 = D-Phe, X = Nle, Glu-19 = γ-Glu, Lys-22 = ε-Lys, Cyclized = Glu-19 -Lys-22, Ile-31 = C-terminal amide) |
| 参考文献 | Martinezet al (1999) Peripheral injection of a new corticotropin-releasing factor (CRF) antagonist, astressin, blocks peripheral CRF- and abdominal surgery-induced delayed gastric emptying in rats. J.Pharmacol.Exp.Ther. 290 629. PMID: 10411571. Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312. PMID: 10816663. Maeckeret al (1997) Astressin, a novel and potent CRF antagonist, is neuroprotective in the hippocampus when administered after a seizure. Brain Res. 744 166. PMID: 9030428. Gulyaset al (1995) Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor. Proc.Natl.Acad.Sci.U.S.A. 92 10575. PMID: 7479843. |