| 货号 | 4812/100U |
| 供应商 | Tocris |
| 生物活性 | Potent and selective KV1.3 channel blocker (IC50 values are 0.0019 and 0.65 nM for KV1.3 and KV1.1, respectively). Inhibits CD4+CCR7- T cell activation. Ameliorates rat experimental autoimmune encephalomyelitis, in a model for multiple sclerosis. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4071.86 |
| 分子式 | C169H281N57O |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | VGINVKCKHSRQCLKPCKDAGMRFGKCTNG (Modifications: Disulfide bridge: 7 - 27, 13 - 32, 17 - 34) |
| 参考文献 | Liet al (2012) Selective inhibition of CCR7(-) effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis model. J.Biol.Chem. 287 29479. PMID: 22761436. Hanet al (2008) Structural basis of a potent peptide inhibitor designed for KV1.3 channel, a therapeutic target of autoimmune disease. J.Biol.Chem. 283 19058. PMID: 18480054. |