| 货号 | 1092/1 |
| 供应商 | Tocris |
| 生物活性 | Potent agonist of the nociceptin (ORL1) receptor, demonstrated both in vitroandin vivo. Selective, competitive antagonism at the nociceptin receptor has also been reported (pA2 = 7.02 and 6.75 in the guinea pig ileum and mouse vas deferens respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1367.6 |
| 分子式 | C61H102N22O14 |
| 可溶性/溶解性 | Soluble to 0.70 mg/ml in water |
| 序列号 | FGGFTGARKSARK (Modifications: Phe-1 - Gly-2 peptide bond replace with Psi-(CH2-NH), Lys-13 = C-terminal amide) |
| 参考文献 | Okawaet al (1999) Comparison of the effects of [Phe1ω(CH2-NH)Gly2-nociceptin-(1-13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors. Br.J.Pharmacol. 127 123. PMID: 10369464. Guerriniet al (1998) A new selective antagonist of the nociceptin receptor. Br.J.Pharmacol. 123 163. PMID: 9489602. Xuet al (1998) [Phe1ω(CH2-NH)Gly2-nociceptin-(1-13)NH2, a proposed antagonist of the nociceptin receptor, is a potent and stable agonist in the rat spinal cord. Neurosci.Lett. 249 127. PMID: 9682833. Guerriniet al (1997) Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin (1-13)-peptide amide. J.Med.Chem. 40 1789. PMID: 9191955. |