| 货号 | 1308/1 |
| 供应商 | Tocris |
| 生物活性 | Selective and competitive nociceptin receptor antagonist, devoid of any agonist activity. Binds selectively to recombinant nociceptin receptors (pKi = 8.4), and competitively antagonizes the actions of nociceptin in vitroandin vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1381.6 |
| 分子式 | C61H100N22O15 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in 10% acetonitrile |
| CAS号 | 267234-08-2 |
| 序列号 | GGGFTGARKSARK (Modifications: Gly-1 = N-Bn-Gly, Lys-13 = C-terminal amide) |
| 参考文献 | Caloet al (2000) Characterization of [Nphe1]nociceptin(1-13)NH2, a new selective nociceptin receptor antagonist. Br.J.Pharmacol. 129 1183. PMID: 10725267. Hashimotoet al (2000) Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor. Neurosci.Lett. 278 109. PMID: 10643813. Phenget al (2000) [Nphe1]nociceptin-(1-13)NH2 selectively antagonizes nociceptin effects in the rabbit isolated ileum. Eur.J.Pharmacol. 397 383. PMID: 10844138. |