| 货号 | 3436/200U |
| 供应商 | Tocris |
| 生物活性 | Potent neuropeptide Y (NPY) Y5 receptor agonist (pEC50 values are 7.82, 6.28, 6.44 and > 6 at rat Y5, Y4, Y1 and Y2 receptors respectively) that displays > 26-fold, > 1000-fold and > 1000-fold selectivity over Y1, Y2 and Y4 receptors respectively. Induces hyperphagia, body weight gain, adiposity, hypercholesterolemia, hyperinsulinemia and hyperleptinemia in vivo. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4311.77 |
| 分子式 | C196H289N55O |
| 可溶性/溶解性 | Soluble to 0.20 mg/ml in 20% acetonitrile |
| 序列号 | YPSKPDNPGEDAPAEDLARYYSALRHYINL (Modifications: Trp-34 = D-Trp, Tyr-36 = C-terminal amide) |
| 参考文献 | Becket al (2007) Responsiveness of obese Zucker rats to [D-Trp34]-NPY supports the targeting of Y5 receptor for obesity treatment. Nutr.Neurosci. 10 211. PMID: 18284029. Mashikoet al (2003) Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: chronic intracerebroventricular infusion of D-Trp34NPY. Endocrinology 144 1793. PMID: 12697685. Parkeret al (2000) [D-Trp34] neuropeptide Y is a potent and selective neuropeptide Y Y5 receptor agonist with dramatic effects on food intake. Peptides 21 393. PMID: 10793222. |