Exendin-3 (9-39) amide
货号：
19890-1mg 基本售价：
4732.0 元 规格：
1 mg
产品信息
概述| 货号 | 19890-1mg |
| 描述 | Exendin-3 (9-39) amide is a truncated form of the exendin-4 (Item No. 11096) peptide that acts as a potent competitive antagonist for the glucagon-like peptide 1 receptor (GLP-1R; Kd = 1.7 nM in CHL cells transfected with cloned human GLP-1).1 It inhibits exendin-3-induced increases in cAMP levels in guinea pig pancreas cells (IC50 = 20 nM).2 Exendin-3 (9-39) amide administration in the hypothalamus (10 and 100 µg, i.c.v.) reverses GLP-1 inhibition of feeding behavior in rats.3 |
| 别名 | Exendin (9-39); |
性能| 供应商 | Cayman |
| 应用文献 |
1.Thorens, B.,Porret, A.,Bühler, L., et al. Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes 42(11), 1678-1682 (1993).
2.Ruffman, J.-P.,Singh, L., and Eng, J. Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin receptor antagonist. J. Biol. Chem. 266(5), 2897-2908 (1991).
3.Turton, M.D.,OShea, D.,Gunn, I., et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379(6560), 69-72 (1996).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 3369.8 |
| 分子式 | C149H234N40O47S |
| CAS号 | 133514-43-9 |
| 稳定性 | ≥ 2 years |
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