N6-benzoyl-Cyclic AMP (sodium salt)
货号：
18819-10mg 基本售价：
4732.0 元 规格：
10 mg
产品信息
概述| 货号 | 18819-10mg |
| 描述 | N6-benzoyl-Cyclic AMP (6-bnz-cAMP) is a cell permeable cAMP analog that selectively activates PKA over exchange proteins activated by cAMP (Epac1 and 2, also known as RAPGEF3 and 4).1 It binds the AI and AII subunits of PKA with pKi values of 4.0 and 3.8, respectively, whereas it binds Epac1 with a pKi value of 1.3.2 6-bnz-cAMP stimulates the phosphorylation of the PKA substrate CREB but does not activate the Epac target Rap1.2 It can act synergistically with Epac-selective activators, such as 8-pCPT-2’-O-Me-cAMP (Item No. 17143).3,2 |
| 别名 | 6-Bnz-cAMP; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Schwede, F.,Maronde, F.,Genieser, H., et al. Cyclic nucleotide analogs as biochemical tools and prospective drugs. Pharmacology & Therapeutics 87(2), 199-226 (2000).
2.Christensen, A.E.,Selheim, F.,de Rooij, J., et al. cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. The Journal of Biological Chemisty 278(37), 35394-35402 (2003).
3.Hewer, R.C.,Sala-Newby, G.B.,Wu, Y.J., et al. PKA and Epac synergistically inhibit smooth muscle cell proliferation. J.Mol.Cell Cardiol. 50(1), 87-98 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 455.3 |
| 分子式 | C17H15N5O7P • Na |
| CAS号 | 1135306-29-4 |
| 稳定性 | ≥ 2 years |
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