| 货号 | 16449-25mg |
| 描述 | TNP-470 is a synthetic analog of fumagillin (Item No. 11332) that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 µM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo.1,2,3 It is without effect on MetAP1.1 TNP-470 has therapeutic potential in cancer and microsporidiosis.3,4 |
| 别名 | AGM-1470;O-(Chloroacetyl-carbamoyl) Fumagillol;NSC 642492; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chen, X.,Xie, S.,Bhat, S., et al. Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chemistry & Biology 16(2), 193-202 (2009). 2.Yanase, T.,Tamura, M.,Rujita, K., et al. Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo. Cancer Research 53(11), 2566-2570 (1993). 3.Drahl, C.,Cravatt, B.F. and Sorensen, E.J. Protein-reactive natural products. Angewandte Chemie International Edition 44, 5788-5809 (2005). 4.Gervaz, P. and Fontolliet, C. Therapeutic potential of the anti-angiogenesis drug TNP-470. International Journal of Experimental Pathology 79(6), 359-362 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 401.9 |
| 分子式 | C19H28ClNO6 |
| CAS号 | 129298-91-5 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |