Dinaciclib
货号：
14707-25mg 基本售价：
4732.0 元 规格：
25 mg
产品信息
概述| 货号 | 14707-25mg |
| 描述 | Cyclin-dependent kinases (CDKs) are critical positive regulators of cell cycle progression and cellular transcription whose dysregulation can lead to the development of cancer. Dinaciclib inhibits CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC50 values of 3, 1, 1, and 4 nM, respectively.1 Compared to the pan-CDK inhibitor flavopiridol (Item No. 10009197), dinaciclib is an equally potent inhibitor of CDK1 and CDK9 but a 12-14-fold more potent inhibitor of CDK2 and CDK5.1 It has been shown to inhibit DNA synthesis by blocking thymidine incorporation in A2780 ovarian cancer cells with an IC50 value of 4 nM.1 At 5 mg/kg it prevents tumor growth by 50% in an A2780 ovarian carcinoma mouse xenograft model and is active against a broad spectrum of human tumor cell lines in vitro(IC50s = 7-17 nM).1 |
| 别名 | SCH 727965; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Parry, D.,Guzi, T.,Shanahan, F., et al. Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor. Molecular Cancer Therapeutics 9(8), 2344-2353 (2010).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 396.5 |
| 分子式 | C21H28N6O2 |
| CAS号 | 779353-01-4 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
